KMID : 1188320160100010574
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Gut and Liver 2016 Volume.10 No. 1 p.574 ~ p.580
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Usefulness of Measuring Serum Procalcitonin Levels in Patients with Inflammatory Bowel Disease
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Chung Sook-Hee
Lee Hye-Won Kim Seung-Won Park Soo-Jung Hong Sung-Pil Kim Tae-Il Kim Won-Ho Cheon Jae-Hee
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Abstract
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Background/Aims:The relationships between serum procalcitonin, inflammatory bowel disease (IBD) and intestinal Behcet¡¯s disease (BD) have not been completely determined. We aimed to evaluate the usefulness of measuring serum procalcitonin levels to assess disease activity and infection stage in patients with IBD and intestinal BD.
Methods:We retrospectively analyzed clinical data from 129 patients with IBD and intestinal BD for whom serum procalcitonin and C-reactive protein (CRP) levels were measured between January 2006 and February 2013.
Results:The median serum procalcitonin levels in the IBD and intestinal BD with septic shock or sepsis (n=8), with localized infection (n=76), and without infection (n=45) were 3.46 ng/mL (range, 0.17 to 63.66 ng/mL), 0.22 ng/mL (range, 0.05 to 140.18 ng/mL), and 0.07 ng/mL (range, 0.00 to 31.50 ng/mL), respectively (p=0.001). The serum CRP levels in the IBD and intestinal BD patients did not differ according to the infection stage. Variations in serum procalcitonin levels were not observed in the IBD and intestinal BD patients with different disease activities.
Conclusions:Serum procalcitonin levels may not be affected by IBD and intestinal BD activity itself, although they may be affected by concomitant infection. Serum procalcitonin measurements could be more useful than CRP in determining the infection stage that reflects the severity of infection in IBD and intestinal BD patients.
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KEYWORD
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Procalcitonin, Inflammatory bowel disease, Intestinal Behcet¡¯s disease, Infection, Disease activity
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